Antimutagenic evaluation of vitamins B1, B6 and B12 in vitro and in vivo, with the Ames test.

@article{ArriagaAlba2013AntimutagenicEO,
  title={Antimutagenic evaluation of vitamins B1, B6 and B12 in vitro and in vivo, with the Ames test.},
  author={Myriam Arriaga-Alba and Nancy J Ruiz-P{\'e}rez and Jaime S{\'a}nchez-Navarrete and Beatriz L{\'o}pez de Angel and Jorge Flores-Lozada and Jos{\'e} Luis Blasco},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2013},
  volume={53},
  pages={
          228-34
        }
}
The aim of this work is to evaluate vitamins B antimutagenic effect against alkylatings methyl-N-nitro-N-nitrosoguanidine (MNNG), ethyl-N-nitro-N'- nitrosoguanidine (ENNG), frameshift mutagens 2-aminoanthracene (2AA) and 2-acetyl-amino-fluorene (2AF) and ROS-generating antibiotics norfloxacin (NOR) and nalidixic acid (NLX), using the in vitro Ames test. In vivo antimutagenesis studies were performed against urinary mutagens induced by NOR (70 mg/kg) or NLX (100 mg/kg) in CD1 mice. Vitamin B1… Expand
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