Antimutagenic activity of organosulfur compounds from Allium is associated with phase II enzyme induction.

@article{Guyonnet2001AntimutagenicAO,
  title={Antimutagenic activity of organosulfur compounds from Allium is associated with phase II enzyme induction.},
  author={Denis Guyonnet and Christine Belloir and Marc Suschetet and Martin Siess and Anne-Marie le Bon},
  journal={Mutation research},
  year={2001},
  volume={495 1-2},
  pages={135-45}
}
In a previous study, we showed that naturally occurring organosulfur compounds (OSCs) from garlic and onion modulated the activation of carcinogen via the alteration of cytochromes P450. The present study was undertaken to determine the incidence of the in vivo induction of phase II enzymes by individual OSCs on the genotoxicity of several carcinogens. Diallyl sulfide (DAS), diallyl disulfide (DADS), dipropyl sulfide (DPS) and dipropyl disulfide (DPDS), were administered by gavage (1mmol/kg) to… CONTINUE READING

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