Antimutagenic action of methionine in Chinese hamster fibroblasts: an opposite of methionine mutagenicity.

Abstract

Serially propagated fibroblast clones were treated with 25-mM methionine and a thioguanine resistance assay was performed at each passage to measure mutagenesis at the HGPRT locus. The spontaneous frequency of thioguanine resistant mutants before treatment was less than 5 X 10(-6) in four clones and 22 X 10(-6) in one clone. These values dropped 10- to 100… (More)

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@article{Hill1988AntimutagenicAO, title={Antimutagenic action of methionine in Chinese hamster fibroblasts: an opposite of methionine mutagenicity.}, author={M. Hill and Jana Hillova and R{\'e}gine Mariage-Samson and Zbynek Brada}, journal={Anticancer research}, year={1988}, volume={8 4}, pages={701-5} }