Antimuscarinic properties of antidepressants: Dibenzepin (Noveril®)

@article{Rehavi1977AntimuscarinicPO,
  title={Antimuscarinic properties of antidepressants: Dibenzepin (Noveril{\textregistered})},
  author={Moshe Rehavi and Saul Maayani and Leon Goldstein and Marcel Assael and Mordechai. Sokolovsky},
  journal={Psychopharmacology},
  year={1977},
  volume={54},
  pages={35-38}
}
The antimuscarinic potency of dibenzepin (Noveril®) was estimated by measuring (a) central in vivo effects in mice (antihypothermia and antitremor, both induced by oxotremorine), (b) peripheral in vivo activity (mydriasis caused by systemic administration of the drug), (c) the effects of dibenzepin on isolated smooth muscle from guinea pig ileum, and (d) in vitro determination of the affinity constant of dibenzepin toward the muscarinic binding sites in whole mouse-brain homogenate.The data… 

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