Antimuscarinic antibodies in primary Sjögren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells.

@article{Dawson2006AntimuscarinicAI,
  title={Antimuscarinic antibodies in primary Sj{\"o}gren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells.},
  author={Luke Dawson and Janice Stanbury and Neil Venn and B Hasdimir and S. N. Rogers and Peter M Smith},
  journal={Arthritis and rheumatism},
  year={2006},
  volume={54 4},
  pages={1165-73}
}
OBJECTIVE Sjögren's syndrome (SS) is an autoimmune condition affecting salivary glands, for which a clearly defined pathogenic autoantibody has yet to be identified. Autoantibodies that bind to the muscarinic M3 receptors (M3R), which regulate fluid secretion in salivary glands, have been proposed in this context. However, there are no previous data that directly show antisecretory activity. This study was undertaken to investigate and characterize the antisecretory activity of anti-M3R… CONTINUE READING
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