Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid.

@article{Kruczynski1998AntimitoticAT,
  title={Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid.},
  author={Anna Kruczynski and Jean Marc Barret and Chantal Eti{\'e}vant and F. C. Colpaert and J. B. Fahy and Bridget T. Hill},
  journal={Biochemical pharmacology},
  year={1998},
  volume={55 5},
  pages={635-48}
}
This study aimed to define the mechanism of action of vinflunine, a novel Vinca alkaloid synthesised from vinorelbine using superacidic chemistry and characterised by superior in vivo activity to vinorelbine in preclinical tumour models. In vitro vinflunine cytotoxicity proved dependent on concentration and exposure duration, with IC50 values (72-hr exposures) generally ranging from 60-300 nM. Vinflunine induced G2 + M arrest, associated with mitotic accumulation and a concentration-dependent… CONTINUE READING
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