Antimitotic and antifungal C-3/C-3''-biflavanones from Stellera chamaejasme.

Abstract

Two new C-3/C-3'' biflavanones, chamaejasmenin D (1) and isochamaejasmenin B (2), were isolated from the roots of Stellera chamaejasme, together with five known biflavanones, chamaejasmenin A (3), chamaejasmenin B (4), neochamaejasmin A (5), sikokianin A (6), and chamaejasmenin C (7). Their structures were elucidated by spectroscopic methods, including 2D NMR techniques. Among these compounds, 1-3 demonstrated potent antimitotic and antifungal activity with minimum inhibitory concentration (MIC) values of 6.25, 6.25, and 3.12 microg/ml, respectively.

Cite this paper

@article{Yang2005AntimitoticAA, title={Antimitotic and antifungal C-3/C-3''-biflavanones from Stellera chamaejasme.}, author={Guohong Yang and Zhi-Xin Liao and Zhiyong Xu and Huiping Zhang and Dao-feng Chen}, journal={Chemical & pharmaceutical bulletin}, year={2005}, volume={53 7}, pages={776-9} }