Antimicrobials: modes of action and mechanisms of resistance.

  title={Antimicrobials: modes of action and mechanisms of resistance.},
  author={Patrick F Mcdermott and Robert D. Walker and David Gordon White},
  journal={International journal of toxicology},
  volume={22 2},
After six decades of widespread antibiotic use, bacterial pathogens of human and animal origin are becoming increasingly resistant to many antimicrobial agents. Antimicrobial resistance develops through a limited number of mechanisms: (a). permeability changes in the bacterial cell wall/membrane, which restrict antimicrobial access to target sites; (b). active efflux of the antimicrobial from the cell; (c). mutation in the target site; (d). enzymatic modification or degradation of the… CONTINUE READING

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