Antimicrobial therapy in patients with impaired renal function.

  title={Antimicrobial therapy in patients with impaired renal function.},
  author={George R. Aronoff},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  volume={3 2},
In order to formulate a thoughtful and rational approach to drug dosing in renal failure, the nephrologist must consider several features that influence drug disposition in uremia. Drug bioavailability is generally adversely influenced in patients with renal disease. Drug distribution is frequently altered to an unpredictable degree. Drug protein binding is affected not only by changes in the amount of circulating binding protein but also by the accumulation of endogenous toxins. Renal failure… CONTINUE READING

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