Antimicrobial resistance is not only increasing the healthcare costs but also the severity and death rates from certain infections that could have been avoided by prudent and rational use of the existing and newer antimicrobial agents. Prudent and rational use of antimicrobial is possible by forming local, national and global wide antibiogram. The present study is undertaken to prepare local antibiogram of Klebsiella pneumoniae (K. pneumoniae) isolated from pus and to discuss general issues related to antimicrobials use. Total 198 pus samples were processed for culture sensitivity testing. Out of 198 pus samples, 142 organisms were isolated. Staphylococcus aureus (36.7%) accounted most common organism and K. pneumoniae(21.1 %) accounted 2 most common organism. Other organisms were Pseudomonas spp. (18.3 %), Escherichia coli (12.7 %), streptococci aureus (9.8 %) and Proteus spp. (1.4 %).Antimicrobial susceptibility testing was done by disk diffusion method described by Kirby-Bauer (1961). K. pneumonia was found to be most sensitive to amikacin, gatifloxacin, gentamicin and chloramphenicol. Consequently, considering the antimicrobial susceptibility, cost, side effects and many other factors, amikacin, gatifloxacin, gentamicin and chloramphenicol should be preferred drugs for K. pneumoniae infection isolated from pus.