Antimicrobial resistance: factors and outcomes.

@article{Fish2006AntimicrobialRF,
  title={Antimicrobial resistance: factors and outcomes.},
  author={Douglas N. Fish and Martin J. Ohlinger},
  journal={Critical care clinics},
  year={2006},
  volume={22 2},
  pages={291-311, vii}
}
Antimicrobial resistance in the ICU is characterized by increasing overall resistance rates among gram-negative and gram-positive pathogens and increased frequency of multidrug-resistant organisms. In addition to basic principles of appropriate drug selection for empiric and definitive therapy, other specific strategies that may decrease problems of resistance through improved use of antimicrobials include appropriate application of pharmacokinetic and pharmacodynamic principles to… CONTINUE READING
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