Antimicrobial prophylaxis in open lower extremity fractures

  title={Antimicrobial prophylaxis in open lower extremity fractures},
  author={Amanda Hyre Anderson and April D. Miller and P Brandon Bookstaver},
  booktitle={Open access emergency medicine : OAEM},
CLINICAL QUESTION Based on the grade of open fracture, which antibiotic should be selected for antimicrobial prophylaxis, and what is the optimal timing and duration of administration? RESULTS For Grade I and II open fractures, a first-generation cephalosporin (eg, cefazolin) should be administered within 3 hours of initial injury and be continued for 24… CONTINUE READING