Antimicrobial prophylaxis for major head and neck surgery in cancer patients.

@article{Grard1988AntimicrobialPF,
  title={Antimicrobial prophylaxis for major head and neck surgery in cancer patients.},
  author={Mich{\`e}le G{\'e}rard and Françoise Meunier and Ph. Dor and Guy Andry and Gilbert Chantrain and Philippe van der Auwera and D. Daneau and Jean A. Klastersky},
  journal={Antimicrobial agents and chemotherapy},
  year={1988},
  volume={32 10},
  pages={1557-9}
}
A total of 113 patients were randomly allocated to receive either ticarcillin plus clavulanic acid (total dose, 20.8 g) or clindamycin (total dose, 2.4 g) plus amikacin (total dose, 1 g) as perioperative antimicrobial prophylaxis for major head and neck surgery. The two groups were similar in age, prior antineoplastic treatment (surgery, chemotherapy, and radiotherapy) or tracheostomy, and the various types of surgery including radical neck dissection. The wound infection rate was 10% in the… CONTINUE READING

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