Antimicrobial prophylaxis for arthroplasty: a comparative study of cefonicid and cefazolin.

@article{Davis1987AntimicrobialPF,
  title={Antimicrobial prophylaxis for arthroplasty: a comparative study of cefonicid and cefazolin.},
  author={Wayne A. Davis and Johji Kane},
  journal={Orthopedics},
  year={1987},
  volume={10 10},
  pages={1405-9}
}
A double-blind, multicenter trial compared cefonicid and cefazolin for prophylaxis against postoperative infection in 117 patients undergoing joint replacement. Cefonicid, which has an extended serum half-life, was administered once daily, while cefazolin was given every eight hours. The drug was administered one half to one hour before surgery and continued for up to 72 hours. Patients were observed throughout their hospitalization period and followed for 30 days after discharge. No evidence… CONTINUE READING