Antimicrobial properties of membrane-active dodecapeptides derived from MSI-78.

  title={Antimicrobial properties of membrane-active dodecapeptides derived from MSI-78.},
  author={Claudia Monteiro and Mariana dos Santos Fernandes and Marina Pinheiro and S{\'i}lvia R Maia and Catarina Leal Seabra and Frederico Ferreira-da-Silva and Fab{\'i}ola Costa and Salette Reis and Paula A C Gomes and M Cristina L Martins},
  journal={Biochimica et biophysica acta},
  volume={1848 5},
Antimicrobial peptides (AMPs) are a class of broad-spectrum antibiotics known by their ability to disrupt bacterial membranes and their low tendency to induce bacterial resistance, arising as excellent candidates to fight bacterial infections. In this study we aimed at designing short 12-mer AMPs, derived from a highly effective and broad spectrum synthetic AMP, MSI-78 (22 residues), by truncating this peptide at the N- and/or C-termini while spanning its entire sequence with 1 amino acid (aa… CONTINUE READING
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