Antimicrobial properties and mode of action of the pyrrothine holomycin.

@article{Oliva2001AntimicrobialPA,
  title={Antimicrobial properties and mode of action of the pyrrothine holomycin.},
  author={Brunello Oliva and Audrey K O'Neill and Jennifer M. Wilson and Peter J. O'hanlon and I Chopra},
  journal={Antimicrobial agents and chemotherapy},
  year={2001},
  volume={45 2},
  pages={
          532-9
        }
}
Holomycin, a member of the pyrrothine class of antibiotics, displayed broad-spectrum antibacterial activity, inhibiting a variety of gram-positive and gram-negative bacteria, with the exception of Enterobacter cloacae, Morganella morganii, and Pseudomonas aeruginosa. The antibiotic lacked activity against the eukaryotic microorganisms Saccharomyces cerevisiae and Candida kefyr. Holomycin exhibited a bacteriostatic response against Escherichia coli that was associated with rapid inhibition of… CONTINUE READING

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