Antimicrobial peptides with stability toward tryptic degradation.

@article{Svenson2008AntimicrobialPW,
  title={Antimicrobial peptides with stability toward tryptic degradation.},
  author={J. Svenson and W. Stensen and B. Brandsdal and B. Haug and J. Monrad and J. Svendsen},
  journal={Biochemistry},
  year={2008},
  volume={47 12},
  pages={
          3777-88
        }
}
The inherent instability of peptides toward metabolic degradation is an obstacle on the way toward bringing potential peptide drugs onto the market. Truncation can be one way to increase the proteolytic stability of peptides, and in the present study the susceptibility against trypsin, which is one of the major proteolytic enzymes in the gastrointestinal tract, was investigated for several short and diverse libraries of promising cationic antimicrobial tripeptides. Quite surprisingly, trypsin… Expand
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