Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells

@article{Suttmann2008AntimicrobialPO,
  title={Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells},
  author={Henrik Suttmann and Margitta M Retz and Friedrich Paulsen and J{\"u}rgen Harder and Ulrike Zwergel and Joern Kamradt and Bernd Wullich and Gerhard Unteregger and Michael St{\"o}ckle and Jan Lehmann},
  journal={BMC Urology},
  year={2008},
  volume={8},
  pages={5 - 5}
}
BACKGROUND This study evaluated the cytotoxic and antiproliferative efficacy of two well-characterized members of the Cecropin-family of antimicrobial peptides against bladder tumor cells and benign fibroblasts. METHODS The antiproliferative and cytotoxic potential of the Cecropins A and B was quantified by colorimetric WST-1-, BrdU- and LDH-assays in four bladder cancer cell lines as well as in murine and human fibroblast cell lines. IC50 values were assessed by logarithmic extrapolation… CONTINUE READING