Antimicrobial peptides from amphibian skin: what do they tell us?

  title={Antimicrobial peptides from amphibian skin: what do they tell us?},
  author={Maurizio Simmaco and Giuseppina Mignogna and Donatella Barra},
  volume={47 6},
Amphibian skin secretions contain many biologically active compounds, such as biogenic amines, complex alkaloids, or peptides. Within the latter class of molecules, a large number of peptide antibiotics has been isolated and characterized from different amphibian species. Antimicrobial peptides are considered the effector molecules of innate immunity, acting as a first line of defense against bacterial infections, by perturbing the phospholipid bilayer of the target cell membrane. These gene… CONTINUE READING