Antimicrobial peptide LL-37 internalized by immature human dendritic cells alters their phenotype.

@article{Bandholtz2006AntimicrobialPL,
  title={Antimicrobial peptide LL-37 internalized by immature human dendritic cells alters their phenotype.},
  author={Lisa Bandholtz and Gunilla Jacobsson Ekman and Monica Vilhelmsson and Eva Buentke and Birgitta Agerberth and A Scheynius and Gudmundur Hrafn Gudmundsson},
  journal={Scandinavian journal of immunology},
  year={2006},
  volume={63 6},
  pages={410-9}
}
The human cathelicidin LL-37 has been shown to be involved in the barrier function of the innate immunity, being released from specific cells upon challenge and exerting immunomodulatory effects. We here demonstrate that LL-37 affects immature dendritic cells, derived from human peripheral blood monocytes (MDDC). LL-37 is internalized by MDDC with subsequent localization primarily in the cytoplasmic compartment. However, LL-37 could also be detected in the nuclei of MDDC, suggesting that LL-37… CONTINUE READING