Antimicrobial penetration and efficacy in an in vitro oral biofilm model.

  title={Antimicrobial penetration and efficacy in an in vitro oral biofilm model.},
  author={Audrey Corbin and Betsey Pitts and Albert E. Parker and Philip S Stewart},
  journal={Antimicrobial agents and chemotherapy},
  volume={55 7},
The penetration and overall efficacy of six mouthrinse actives was evaluated by using an in vitro flow cell oral biofilm model. The technique involved preloading biofilm cells with a green fluorescent dye that leaked out as the cells were permeabilized by a treatment. The loss of green color, and of biomass, was observed by time-lapse microscopy during 60 min of treatment under continuous flow conditions. The six actives analyzed were ethanol, sodium lauryl sulfate, triclosan, chlorhexidine… CONTINUE READING


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Efficacy of two alcohol-free cetylpyridinium chloride mouthwashes: a randomized double-blind crossover study

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