Antimicrobial management strategies for Gram-positive bacterial resistance in the intensive care unit.

@article{Schentag2001AntimicrobialMS,
  title={Antimicrobial management strategies for Gram-positive bacterial resistance in the intensive care unit.},
  author={JeromeJ. Schentag},
  journal={Critical care medicine},
  year={2001},
  volume={29 4 Suppl},
  pages={
          N100-7
        }
}
This article summarizes the current situation with Gram-positive infections, including the two primary consequences-failure to cure and resistance-relevant to the intensive care unit. The past few years have seen Enterococcus faecium resistance to vancomycin increase from 10% of strains to approaching 60% of strains in some centers. Failure is now so frequent that vancomycin can no longer be safely used. This has lead to use of two new antibiotics, quinupristin/dalfopristin (Synercid), first… CONTINUE READING
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