Antimicrobial histones and DNA traps in invertebrate immunity: evidences in Crassostrea gigas.

@article{Poirier2014AntimicrobialHA,
  title={Antimicrobial histones and DNA traps in invertebrate immunity: evidences in Crassostrea gigas.},
  author={Aurore C Poirier and Paulina Schmitt and Rafael Diego Rosa and Audrey Sophie Vanhove and Sylvie Kieffer-Jaquinod and Tristan P Rubio and Guillaume M. Charri{\`e}re and Delphine Destoumieux-Garz{\'o}n},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 36},
  pages={24821-31}
}
Although antimicrobial histones have been isolated from multiple metazoan species, their role in host defense has long remained unanswered. We found here that the hemocytes of the oyster Crassostrea gigas release antimicrobial H1-like and H5-like histones in response to tissue damage and infection. These antimicrobial histones were shown to be associated with extracellular DNA networks released by hemocytes, the circulating immune cells of invertebrates, in response to immune challenge. The… CONTINUE READING

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