Antimicrobial endodontic compounds do not modulate alkylation-induced genotoxicity and oxidative stress in vitro.


OBJECTIVE To investigate if formocresol, paramonochlorophenol, or calcium hydroxide modulate the genotoxic effects induced by the oxidatively damaging agent hydrogen peroxide (H2O2) or the alkylating agent methyl methanesulfonate (MMS) in vitro by using single cell gel (comet) assay. STUDY DESIGN Chinese hamster ovary (CHO) cells in culture were exposed… (More)