Antimicrobial effects of nanofiber poly(caprolactone) tissue scaffolds releasing rifampicin.

@article{Ruckh2012AntimicrobialEO,
  title={Antimicrobial effects of nanofiber poly(caprolactone) tissue scaffolds releasing rifampicin.},
  author={Timothy T. Ruckh and Rachael A. Oldinski and Derek A. Carroll and Krasimira Mikhova and James D Bryers and Ketul C. Popat},
  journal={Journal of materials science. Materials in medicine},
  year={2012},
  volume={23 6},
  pages={1411-20}
}
This study quantified the antibiotic release kinetics and subsequent bactericidal efficacy of rifampicin (RIF) against Gram-positive and Gram-negative bacteria under in vitro static conditions. Antibiotic-loaded scaffolds were fabricated by electrospinning poly(caprolactone) (PCL) with 10% or 20% (w/w) RIF. Scaffold fiber diameter and RIF loading were characterized, and RIF release kinetics were measured. RIF-releasing and RIF-free scaffolds were inoculated with Pseudomonas aeruginosa and… CONTINUE READING