Antimicrobial effects of alpha-MSH peptides.

  title={Antimicrobial effects of alpha-MSH peptides.},
  author={Marcello Cutuli and Stefano Cristiani and James M. Lipton and A. Fede Catania},
  journal={Journal of leukocyte biology},
  volume={67 2},
The presence of the ancient anti-inflammatory peptide alpha-melanocyte-stimulating hormone [alpha-MSH (1-13), SYSMEHFRWGKPV] in barrier organs such as gut and skin suggests a role in the nonspecific (innate) host defense. alpha-MSH and and its carboxy-terminal tripeptide (11-13, KPV) were determined to have antimicrobial influences against two major and representative pathogens: Staphylococcus aureus and Candida albicans. alpha-MSH peptides significantly inhibited S. aureus colony formation and… CONTINUE READING