Antimicrobial drug resistance.

  title={Antimicrobial drug resistance.},
  author={Marilyn N. Martinez and Peter Silley},
  journal={Handbook of experimental pharmacology},
This chapter provides an overview of our current understanding of the mechanisms associated with the development of antimicrobial drug resistance, international differences in definitions of resistance, ongoing efforts to track shifts in drug susceptibility, and factors that can influence the selection of therapeutic intervention. The latter presents a matrix of complex variables that includes the mechanism of drug action, the pharmacokinetics (PK) of the antimicrobial agent in the targeted… CONTINUE READING

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