Antimicrobial drug discovery through bacteriophage genomics

@article{Liu2004AntimicrobialDD,
  title={Antimicrobial drug discovery through bacteriophage genomics},
  author={Jing Liu and M. Dehbi and G. Moeck and F. Arhin and P. Bauda and D. Bergeron and M. Callejo and V. Ferretti and N. Ha and T. Kwan and J. McCarty and R. Srikumar and D. Williams and Jinzi J. Wu and P. Gros and J. Pelletier and M. Dubow},
  journal={Nature Biotechnology},
  year={2004},
  volume={22},
  pages={185-191}
}
Over evolutionary time bacteriophages have developed unique proteins that arrest critical cellular processes to commit bacterial host metabolism to phage reproduction. Here, we apply this concept of phage-mediated bacterial growth inhibition to antibiotic discovery. We sequenced 26 Staphylococcus aureus phages and identified 31 novel polypeptide families that inhibited growth upon expression in S. aureus. The cellular targets for some of these polypeptides were identified and several were shown… Expand
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