Antimicrobial drug discovery through bacteriophage genomics

  title={Antimicrobial drug discovery through bacteriophage genomics},
  author={Jing Liu and Mohammed Dehbi and Gregory S. Moeck and Francis F. Arhin and Pascale Bauda and Dominique Bergeron and Mario Callejo and Vincent Ferretti and Nhuan Ha and Tony Kwan and John S. McCarty and Ramakrishnan Srikumar and Daniel M. Williams and Jinzi J. Wu and Philippe Gros and Jerry Pelletier and Michael S. Dubow},
  journal={Nature Biotechnology},
Over evolutionary time bacteriophages have developed unique proteins that arrest critical cellular processes to commit bacterial host metabolism to phage reproduction. Here, we apply this concept of phage-mediated bacterial growth inhibition to antibiotic discovery. We sequenced 26 Staphylococcus aureus phages and identified 31 novel polypeptide families that inhibited growth upon expression in S. aureus. The cellular targets for some of these polypeptides were identified and several were shown… 

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