Antimicrobial drug discovery through bacteriophage genomics

@article{Liu2004AntimicrobialDD,
  title={Antimicrobial drug discovery through bacteriophage genomics},
  author={Jing Liu and Mohammed Dehbi and Greg Moeck and Francis F. Arhin and Pascale Bauda and Dominique Bergeron and Mario Callejo and Vincent Ferretti and Nhuan Ha and Tony Kwan and John H. McCarty and Ramakrishnan Srikumar and David John Williams and Jinzi J Wu and Philippe Gros and Jerry Pelletier and Michael DuBow},
  journal={Nature Biotechnology},
  year={2004},
  volume={22},
  pages={185-191}
}
  • Jing Liu, Mohammed Dehbi, +14 authors Michael DuBow
  • Published 2004
  • Medicine, Biology
  • Nature Biotechnology
  • Over evolutionary time bacteriophages have developed unique proteins that arrest critical cellular processes to commit bacterial host metabolism to phage reproduction. Here, we apply this concept of phage-mediated bacterial growth inhibition to antibiotic discovery. We sequenced 26 Staphylococcus aureus phages and identified 31 novel polypeptide families that inhibited growth upon expression in S. aureus. The cellular targets for some of these polypeptides were identified and several were shown… CONTINUE READING

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