Antimicrobial contact activity of econazole sulfosalicylate.

  title={Antimicrobial contact activity of econazole sulfosalicylate.},
  author={Nicola Simonetti and Giacomo Spignoli and Felicia Diodata D'Auria and V. Strippoli},
  journal={Journal of chemotherapy},
  volume={3 2},
The aim of this investigation was to compare the contact action of econazole sulfosalicylate (E-SSA) on mycetes (Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Trichophyton rubrum, T. cutaneum, Pityrosporum sp.), Gram-positive bacteria (Staphylococcus aureus, Streptococcus faecalis) and Gram-negative bacteria (Escherichia coli, Citrobacter freundii) with that exerted by econazole nitrate (E-NIT). The results show E-SSA activity greater than E-NIT (in particular against… Expand
1 Citations
Antifungal Agents, Part 11: Biphenyl Analogues of Naftifine: Synthesis and Antifungal Activities
A series of naftifine analogues having the biphenyl instead of the naphthyl moiety have been synthesized in a search devoted to study bioanalogues of clinically efficacious antifungal agents. The newExpand


Investigations of the activity by contact of miconazole sulfosalicylate.
M.SSA has a greater activity than M.NIT, particularly on mycetes and Gram-negative bacteria, which could be related to its higher lipophilia and, therefore, to increased interaction with the cell membrane. Expand
Antimicrobial activity of econazole and miconazole in vitro and in experimental candidiasis and aspergillosis.
It is concluded that more studies, especially on the pharmacology of econazole and about the clinical efficacy, are needed to come to a definite judgement. Expand
Mechanisms of action of the antimycotic imidazoles.
The mechanism of the antifungal action of the imidazole antimycotics, miconazole ano clotrimazole, on Saccharomyces cerevisiae was explored and the fungistatic effect correlated with inhibition of ergosterol synthesis and elevated lanosterol/ergosterol ratios in the organisms. Expand
Mode of action of miconazole on Candida albicans: effect on growth, viability and K+ release.
  • J. Cope
  • Biology, Medicine
  • Journal of general microbiology
  • 1980
It is proposed that both the fungistatic and fungicidal actions of miconazole are due to its direct interaction with the cellular membranes of C. albicans rather than to an inhibition of biochemical reactions. Expand
Mode of action of clinically important antifungal drugs.
  • D. Kerridge
  • Biology, Medicine
  • Advances in microbial physiology
  • 1986
This chapter discusses antimycotic drugs that are used in the therapy of human infections and outlines the current knowledge of the mode of action of the clinically important antifungal drugs. Expand