Antimicrobial and immunologic activities of clarithromycin in a murine model of Mycoplasma pneumoniae-induced pneumonia.

@article{Hardy2003AntimicrobialAI,
  title={Antimicrobial and immunologic activities of clarithromycin in a murine model of Mycoplasma pneumoniae-induced pneumonia.},
  author={Robert Doug Hardy and Ana Mar{\'i}a R{\'i}os and Susana Chavez-Bueno and Hasan S. Jafri and Jeanine Hatfield and Beverly Barton Rogers and George H Mccracken and Octavio Ramilo},
  journal={Antimicrobial agents and chemotherapy},
  year={2003},
  volume={47 5},
  pages={1614-20}
}
Because macrolide antibiotics are hypothesized to possess immunomodulatory activity independent of their antimicrobial activity, we evaluated the immunomodulatory effect of clarithromycin in a murine model of lung inflammation induced by either live or UV-killed Mycoplasma pneumoniae. BALB/c mice were intranasally inoculated once with live or UV-killed M. pneumoniae. Clarithromycin (25 mg/kg of body weight) or placebo was subcutaneously administered once daily in both groups of mice. In mice… CONTINUE READING
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Respiratory syncytial virus affects pulmonary function in BALB/c mice

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