Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies

@article{Hancock2006AntimicrobialAH,
  title={Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies},
  author={Robert E. W. Hancock and H. -G. Sahl},
  journal={Nature Biotechnology},
  year={2006},
  volume={24},
  pages={1551-1557}
}
Short cationic amphiphilic peptides with antimicrobial and/or immunomodulatory activities are present in virtually every life form, as an important component of (innate) immune defenses. These host-defense peptides provide a template for two separate classes of antimicrobial drugs. Direct-acting antimicrobial host-defense peptides can be rapid-acting and potent, and possess an unusually broad spectrum of activity; consequently, they have prospects as new antibiotics, although clinical trials to… CONTINUE READING
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