Antimicrobial and cytolytic polypeptides of amoeboid protozoa--effector molecules of primitive phagocytes.

@article{Leippe1999AntimicrobialAC,
  title={Antimicrobial and cytolytic polypeptides of amoeboid protozoa--effector molecules of primitive phagocytes.},
  author={Matthias Leippe},
  journal={Developmental and comparative immunology},
  year={1999},
  volume={23 4-5},
  pages={
          267-79
        }
}
Amoebae are primitive, actively phagocytosing eukaryotic cells, many of which use bacteria as a major nutrient source. One may suppose that amoebae possess an array of potent antimicrobial molecules acting in synergy to combat bacterial growth inside their phagosomes. Lysosome-like granular vesicles of Entamoeba histolytica contain a family of 77-residue peptides with a compact alpha-helical, disulfide-bonded fold. These polypeptides, named amoebapores, exhibit antibacterial and cytolytic… CONTINUE READING
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