Antimicrobial and DNA-binding activities of the peptide fragments of human lactoferrin and histatin 5 against Streptococcus mutans.

@article{Huo2011AntimicrobialAD,
  title={Antimicrobial and DNA-binding activities of the peptide fragments of human lactoferrin and histatin 5 against Streptococcus mutans.},
  author={L. Gao-Y. Zhou-C. Li-L. Huo and Kai Zhang and Jun-qi Ling and Zhixiang Peng and Xiangya Huang and Hongyan Liu and Lisha Gu},
  journal={Archives of oral biology},
  year={2011},
  volume={56 9},
  pages={869-76}
}
OBJECTIVE To investigate the killing effect of two salivary antimicrobial peptides, hLF1-11 and P-113, and identify the antibacterial mechanism of the peptides. METHODS The antimicrobial activities of hLF1-11 and P-113 against oral Streptococci strains were determined using the broth microdilution method. The effects of hLF1-11 and P-113 on the bacterial plasma membrane were visualized by scanning electron microscopy. Cell membrane permeability was monitored using the intracellular dye… CONTINUE READING
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