Antimicrobial and Antiinsectan Phenolic Metabolites of Dalea searlsiae

@article{Belofsky2014AntimicrobialAA,
  title={Antimicrobial and Antiinsectan Phenolic Metabolites of Dalea searlsiae},
  author={Gilbert N. Belofsky and Mario Aronica and Eric J Foss and Jane Diamond and Felipe Santana and Jacob Darley and Patrick F. Dowd and Christina M Coleman and Daneel Ferreira},
  journal={Journal of Natural Products},
  year={2014},
  volume={77},
  pages={1140 - 1149}
}
Continued interest in the chemistry of Dalea spp. led to investigation of Dalea searlsiae, a plant native to areas of the western United States. Methanol extractions of D. searlsiae roots and subsequent chromatographic fractionation afforded the new prenylated and geranylated flavanones malheurans A–D (1–4) and known flavanones (5 and 6). Known rotenoids (7 and 8) and isoflavones (9 and 10) were isolated from aerial portions. Structure determination of pure compounds was accomplished primarily… 

Tables from this paper

Phenolic Metabolites of Dalea ornata Affect Both Survival and Motility of the Human Pathogenic Hookworm Ancylostoma ceylanicum.
TLDR
Using a hamster-based ex vivo assay, anthelmintic activity toward Ancylostoma ceylanicum was observed in the crude extract of aerial parts of Dalea ornata, and these studies have led to the isolation and characterization of phenolic metabolites 1-10.
Preliminary Isolation and Characterization of Root Extract Components of Dalea jamesii
TLDR
This study will be conducted with the hypothesis that unique phenolic secondary metabolites will be produced in the roots of D. jamesii to determine if the isolated metabolites exhibit biomedically related activities and to investigate whether the phenolicsecondary metabolites show any bioactivities.
Penicacids H–J, three new mycophenolic acid derivatives from the marine-derived fungus Rhizopus oryzae
Chemical investigation of secondary metabolites in crude methanol extract of a solid rice medium of a marine-derived fungus, Rhizopus oryzae, has enriched the metabolic profile of this genus by
Dalea Genus, Chemistry, and Bioactivity Studies
...
1
2
3
...

References

SHOWING 1-10 OF 103 REFERENCES
Phenolic metabolites of Dalea versicolor that enhance antibiotic activity against model pathogenic bacteria.
TLDR
A new flavonoid was isolated from organic extracts of Dalea versicolor, along with six known phenolic compounds, which were evaluated for their ability to potentiate the activity of known antimicrobials through inhibition of multidrug-resistance (MDR) pumps.
Isoflavonoids and coumarins from Glycyrrhiza uralensis: antibacterial activity against oral pathogens and conversion of isoflavans into isoflavan-quinones during purification.
Phytochemical investigation of a supercritical fluid extract of Glycyrrhiza uralensis has led to the isolation of 20 known isoflavonoids and coumarins, and glycycarpan (7), a new pterocarpan. The
Fungal ABC transporter-associated activity of isoflavonoids from the root extract of Dalea formosa.
TLDR
The results demonstrate that multiple crude extract compounds are differentially affected by efflux-mediated resistance and are collectively responsible for the observed bioactivity.
Pierreiones A-D, solid tumor selective pyranoisoflavones and other cytotoxic constituents from Antheroporum pierrei.
Bioassay-guided fractionation of a solid tumor selective extract of the leaves and twigs of Antheroporum pierrei acquired from the U.S. National Cancer Institute extract repository afforded four new
Insect antifeedant flavonoids from Gnaphalium affine D. Don.
TLDR
Four natural flavonoids showed insect antifeedant activity against the common cutworm (Spodoptera litura F.) and were regarded as one of the plant's defensive systems against phytophagous insects along with the woolly plant surface.
Antimicrobial activity of flavonoids
Recent advances in understanding the antibacterial properties of flavonoids.
Flavonoids with activity against methicillin-resistant Staphylococcus aureus from Dalea scandens var. paucifolia.
Bioassay-guided fractionation of the ethyl acetate extract of the roots of Dalea scandens (Miller) R. Clausen var. paucifolia led to the isolation of new flavonoids, 2(
Differential Activity of Multiple Saponins Against Omnivorous Insects with Varying Feeding Preferences
TLDR
The activity of protodioscin against insects is reported for the first time and may be important in insect defense by the bioenergy crop switchgrass.
...
1
2
3
4
5
...