Antimicrobial activity profiles of Amphiphilic Xanthone derivatives are a function of their molecular Oligomerization.

@article{Koh2018AntimicrobialAP,
  title={Antimicrobial activity profiles of Amphiphilic Xanthone derivatives are a function of their molecular Oligomerization.},
  author={Jun-Jie Koh and Shuimu Lin and Yang Bai and Wendy Wan Ling Sin and Thet Tun Aung and Jianguo Li and Verma Chandra and Konstantin Pervushin and Roger W. Beuerman and Shouping Liu},
  journal={Biochimica et biophysica acta. Biomembranes},
  year={2018}
}
Currently, membrane-targeting small antimicrobial peptidomimetics (SAP) are important in antibiotic development because bacteria appear to develop resistance to these surface-active compounds less readily. However, the molecular membrane-targeting action of SAPs has received little attention. In this study, we investigated the effect of oligomerization of amphiphilic xanthone, a model SAP, on its antimicrobial properties against both Gram-positive and Gram-negative bacteria. First, oligomer… CONTINUE READING
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