Antimicrobial activity of the bufadienolides marinobufagin and telocinobufagin isolated as major components from skin secretion of the toad Bufo rubescens.

  title={Antimicrobial activity of the bufadienolides marinobufagin and telocinobufagin isolated as major components from skin secretion of the toad Bufo rubescens.},
  author={Geraldino A Cunha Filho and C. A. Schwartz and I. S. Resck and M. M. Murta and S. S. Lemos and M. S. Castro and C. Kyaw and O. R. Pires and J. Leite and C. Bloch and E. F. Schwartz},
  journal={Toxicon : official journal of the International Society on Toxinology},
  volume={45 6},
The increase in the emergence of antibiotic-resistant microorganisms and difficult to treat infections caused by these pathogens stimulate research aiming the identification of novel antimicrobials. Skin secretion of amphibian contains a large number of biologically active compounds, including compounds that performance defense mechanisms against microorganisms. In the present work, two antimicrobial bufadienolides, telocinobufagin (402.1609 Da) and marinobufagin (400.1515 Da), were isolated… Expand
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