Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi.


We report here for the first time the in vitro effects of (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2·2·1]heptan-2-yl-3',4',5'-trimethoxy benzoate (1) and (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2·2·1]heptan-2-yl benzoate (2) on the growth and ultrastructure of Trypanosoma cruzi. These two synthetic compounds exerted an antiproliferative effect on the epimastigote forms of the parasite. The ICs(50/72h) of two synthetic L-bornyl benzoates, 1 and 2, was 10·1 and 12·8 μg/ml, respectively. Both compounds were more selective against epimastigotes than HEp-2 cells. Ultrastructural analysis revealed intense cytoplasmic vacuolization and the appearance of cytoplasmic materials surrounded by membranes. The treatment of peritoneal macrophages with compounds 1 and 2 caused a significant decrease in the number of T. cruzi-infected cells. L-Bornyl benzoate derivatives may serve as a potential source for the development of more effective and safer chemotherapeutic agents against T. cruzi infections.

DOI: 10.1179/2047773212Y.0000000002

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@article{Correa2012AntimicrobialAO, title={Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi.}, author={Pricila Cristina Ribeiro Correa and Roqueline R. S. de Miranda and Lucienir Pains Duarte and Gr{\'a}cia Divina de F{\'a}tima Silva and Sidney Augusto Vieira Filho and Adriana Akemi Okuma and Fernando Carazza and Jos{\'e} Andr{\'e}s Morgado-D{\'i}az and Phileno Pinge-Filho and Lucy Megumi Yamauchi and Celso Vataru Nakamura and Sueli Fumie Yamada-Ogatta}, journal={Pathogens and global health}, year={2012}, volume={106 2}, pages={107-12} }