Antimicrobial activity of selected cyclic dipeptides.

  title={Antimicrobial activity of selected cyclic dipeptides.},
  author={M Graz and Anthony J. Hunt and Hajierah Jamie and Gary D Grant and Pieter J Milne},
  journal={Die Pharmazie},
  volume={54 10},
Cyclic dipeptides are products of rational drug design, which may exhibit both antimicrobial and antitumor properties. The aim of this study was to investigate both the antimicrobial effects of the cyclic dipeptides cyclo(L-phenylalanyl-L-prolyl), cyclo(L-tyrosyl-L-prolyl), cyclo(L-tryptophanyl-L-prolyl) and cyclo(L-tryptophanyl-L-tryptophanyl) and the effects of these cyclic dipeptides on the gastrointestinal epithelium in vitro. Furthermore, a relevant solvent for the possible pharmaceutical… CONTINUE READING