Antimicrobial activity of rabbit CAP18-derived peptides.

  title={Antimicrobial activity of rabbit CAP18-derived peptides.},
  author={James W. Larrick and Masato Hirata and Y Shimomoura and Mayumi Yoshida and Hong Yuan Zheng and Jie Zhong and Susan C. Wright},
  journal={Antimicrobial agents and chemotherapy},
  volume={37 12},
A cationic antimicrobial protein of 18 kDa (CAP18) was originally isolated from rabbit granulocytes by using as an assay the agglutination of Re-lipopolysaccharide-coated erythrocytes. The C-terminal 37 amino acids of CAP18 (CAP18(106-142)) make up the lipopolysaccharide-binding domain. Synthetic CAP18(106-142) has broad antimicrobial activity against both gram-positive (50% inhibitory concentration, 130 to 200 nM) and gram-negative (50% inhibitory concentration, 20 to 100 nM) bacteria… CONTINUE READING
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