Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region.

@article{Santamaria2005AntimicrobialAO,
  title={Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region.},
  author={C. Santamaria and S. Larios and Y. Angulo and J. Pizarro-Cerd{\'a} and J. Gorvel and E. Moreno and B. Lomonte},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2005},
  volume={45 7},
  pages={
          807-15
        }
}
A short peptide derived from the C-terminal region of Bothrops asper myotoxin II, a Lys49 phospholipase A(2) (PLA(2)), was previously found to reproduce the bactericidal activity of its parent molecule. In this study, a panel of eight PLA(2) myotoxins purified from crotalid snake venoms, including both Lys49 and Asp49-type isoforms, were all found to express bactericidal activity, indicating that this may be a common action of the group IIA PLA(2) protein family. A series of 10 synthetic… Expand
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A new muscle damaging toxin, myotoxin II, was purified from the venom of Bothrops asper by ion-exchange chromatography on CM-Sephadex C-25, and immunochemical tests indicate a high degree of homology between this toxin and a previously characterizedMyotoxin I. Expand
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