Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates.

@article{Faccone2014AntimicrobialAO,
  title={Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates.},
  author={Diego F Faccone and Omar Veliz and Alejandra C Corso and Mart{\'i}n Ezequiel Noguera and Melina Mart{\'i}nez and Cristian Pay{\'e}s and Liliana C. Semorile and Paulo C{\'e}sar Maffia},
  journal={European journal of medicinal chemistry},
  year={2014},
  volume={71},
  pages={31-5}
}
Antibiotic resistance is one of the main problems concerning public health or clinical practice. Antimicrobial peptides appear as good candidates for the development of new therapeutic drugs. In this study we de novo designed a group of cationic antimicrobial peptides, analyzed its physicochemical properties, including its structure by circular dichroism and studied its antimicrobial properties against a panel of clinical isolates expressing different mechanisms of resistance. Three cationic… CONTINUE READING