Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone resistance-determining regions.

@article{Hirakata2009AntimicrobialAO,
  title={Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone resistance-determining regions.},
  author={Yoshimi Hirakata and Kaori Ohmori and Miwako Mikuriya and Takeshi Saika and Kaoru Matsuzaki and Miyuki Hasegawa and Masumitsu Hatta and Natsuo Yamamoto and Hiroyuki Kunishima and Hisakazu Yano and Miho Kitagawa and Kazuaki Arai and Kazuyoshi Kawakami and Intetsu Kobayashi and Richard Norman Jones and Shigeru Kohno and Keizo Yamaguchi and Mitsuo Kaku},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 10},
  pages={
          4225-30
        }
}
Beta-lactamase-negative ampicillin-resistant (BLNAR) isolates of Haemophilus influenzae have been emerging in some countries, including Japan. The Clinical and Laboratory Standards Institute has only a susceptible MIC breakpoint (< or = 1 microg/ml) for piperacillin-tazobactam and a disclaimer comment that BLNAR H. influenzae should be considered resistant, which was adapted without presentation of data. In addition, fluoroquinolone-resistant H. influenzae isolates have recently been… CONTINUE READING
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Ampicillin-resistant Haemophilus influenzae isolates in Geneva: serotype, antimicrobial susceptibility, and β-lactam resistance mechanisms

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Global Fluoroquinolone Resistance Epidemiology and Implictions for Clinical Use

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