Antimicrobial actions of hexachlorophene: release of cytoplasmic materials.

  title={Antimicrobial actions of hexachlorophene: release of cytoplasmic materials.},
  author={H L Joswick and T R Corner and J N Silvernale and Philipp Gerhardt},
  journal={Journal of bacteriology},
  volume={108 1},
Intracellular solutes were released from growing or resting cells of Bacillus megaterium as a consequence of hexachlorophene treatment. The effect was dose dependent, with the optimum at a concentration about sevenfold greater than the minimal lethal dose. The effects of pH and temperature on the leakage process also were inconsistent with the killing effects of the drug. The types of materials released appeared to be the same with or without hexachlorophene treatment. The released materials… CONTINUE READING

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