Antimicrobial Peptides as Mediators of Epithelial Host Defense

  title={Antimicrobial Peptides as Mediators of Epithelial Host Defense},
  author={Kenneth M. Huttner and Charles L. Bevins},
  journal={Pediatric Research},
Mammalian epithelial surfaces are remarkable for their ability to provide critical physiologic functions in the face of frequent microbial challenges. The fact that these mucosal surfaces remain infection-free in the normal host suggests that highly effective mechanisms of host defense have evolved to protect these environmentally exposed tissues. Throughout the animal and plant kingdoms, endogenous genetically encoded antimicrobial peptides have been shown to be key elements in the response to… CONTINUE READING
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