Antimicrobial Peptide Novicidin Synergizes with Rifampin, Ceftriaxone, and Ceftazidime against Antibiotic-Resistant Enterobacteriaceae In Vitro.

@article{Soren2015AntimicrobialPN,
  title={Antimicrobial Peptide Novicidin Synergizes with Rifampin, Ceftriaxone, and Ceftazidime against Antibiotic-Resistant Enterobacteriaceae In Vitro.},
  author={O Petersen Soren and Karoline Sidelmann Brinch and Dipesh Manharbhai Patel and Yingjun Liu and Alexander Q. Liu and Anthony Robert Milnes Coates and Yanmin Hu},
  journal={Antimicrobial agents and chemotherapy},
  year={2015},
  volume={59 10},
  pages={
          6233-40
        }
}
The spread of antibiotic resistance among Gram-negative bacteria is a serious clinical threat, and infections with these organisms are a leading cause of mortality worldwide. Traditional novel drug development inevitably leads to the emergence of new resistant strains, rendering the new drugs ineffective. Therefore, reviving the therapeutic potentials of existing antibiotics represents an attractive novel strategy. Novicidin, a novel cationic antimicrobial peptide, is effective against Gram… CONTINUE READING
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