Antimicrobial Chemical Constituents from the Endophytic Fungus Phomopsis sp. from Notobasis syriaca

  title={Antimicrobial Chemical Constituents from the Endophytic Fungus Phomopsis sp. from Notobasis syriaca},
  author={Hidayat Hussain and Michel K. Tchimene and Ishtiaq Ahmed and Kathrin Meier and Michael Steinert and Siegfried Draeger and Barbara Joan Schulz and Karsten Krohn},
  journal={Natural Product Communications},
Phomosine K (1), a new phomosine derivative, has been isolated from Phomopsis sp., in addition to six known compounds: phomosine A (2), phenylalanine amide (3), 2-hydroxymethyl-4β,5α,6β-trihydroxycyclohex-2-en (4), (-)-phyllostine (5), (+)-epiepoxydon (6), and (+)-epoxydon monoacetate (7). Preliminary studies showed that compound 1 had strong antibacterial activity, while compounds 4-7 showed good antifungal, antibacterial, and algicidal properties, except compounds 4 and 6, which lacked… Expand
Phytochemical investigation and antimicrobial activity of an endophytic fungus Phoma sp.
Abstract Phytochemical investigation of the endophytic fungi Phoma sp. resulted in the isolation of sclerodin ( 1 ), 8,9-dihydro-3,5,7-trihydroxy-1,8,8,9-tetramethyl-5-(2-oxopropyl)-4 HExpand
Xanthones from the Fermentation Products of the Endophytic Fungus of Phomopsis amygdali
Two new xanthones, 3-methoxy-1,4,8-trihydroxy-5-(1′,3′,4′-trihydroxybutan-2′-yl)-xanthone (1), 8-methoxy-1,3,4-trihydroxy-5-(1′,3′,4′-trihydroxybutan-2′-yl)-xanthone (2), and three known xanthonesExpand
Seimatoric acid and colletonoic acid: Two new compounds from the endophytic fungi, Seimatosporium sp. and Colletotrichum sp.
Abstract A new metabolite, named seimatoric acid ( 1 ), representing a new oxobutanoic acid derivative has been isolated from Seimatosporium sp., in addition to four known compounds viz. ,Expand
Antimicrobial constituents from three endophytic fungi.
Antimicrobial activities demonstrated by the extracts of the endophytic fungi Plectophomella sp. Expand
Algicidal activity of a dibenzofuran-degrader Rhodococcus sp.
Rhodococcus sp. strain p52, a previously isolated dibenzofuran degrader, could effectively inhibit the growth of cyanobacteria, including species of Microcystis, Anabaena, and Nodularia. When strainExpand
Endophytic fungi: the treasure chest of antibacterial substances.
  • N. Radić, B. Strukelj
  • Biology, Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2012
The accumulated data on endophytic fungi isolated from plants that produce metabolites with antibacterial activity against human pathogenic bacteria are reviewed. Expand
In this study, three extracts of the aerial parts of Notobasis syriaca and Scolymus maculatus were prepared. Each extract was tested for antifungal activity against Rhizopus stolonifer (black mold),Expand
The genus Diaporthe: a rich source of diverse and bioactive metabolites
Not a single metabolite which is also known from the host plant has ever been isolated as a major component from an endophytic Diaporthe strain, despite the fact that many of the recent studies were targeting endophytics fungi of medicinal plants. Expand
Biological activity of Diaporthe terebinthifolii extracts against Phyllosticta citricarpa
The results obtained strongly suggest the existence of a synergistic effect among the metabolites produced in D. terebinthifolii that could be used to control the CBS disease. Expand
Bioactive Secondary Metabolites of the Genus Diaporthe and Anamorph Phomopsis from Terrestrial and Marine Habitats and Endophytes: 2010–2019
This review summarizes a total of 335 bioactive secondary metabolites isolated from 26 known species and various unidentified species of Diaporthe and Phomopsis during 2010–2019, finding 106 bioactive compounds derived from Diapporthe and 246 from Phomops, while 17 compounds are found in both of them. Expand


Metabolites from the Fungus Phoma sp. 7210, Associated with Aizoon Canariense
A new metabolite, 3,16-diketoaphidicolan (1), was isolated together with four known compounds from the endophytic fungus Phoma sp. Expand
Biologically active secondary metabolites of endophytic Pezicula species
Endophytic Pezicula strains were isolated from living branches of ten deciduous and coniferous trees and tested for their fungicidal, algicidal and antibacterial activities and the synthesis of these metabolites in 85 isolates was dependent on conditions of culture and was also found to be taxonomically significant. Expand
New secondary metabolites from the marine endophytic fungus Apiospora montagnei.
The marine fungus Apiospora montagnei was isolated from the inner tissue of the North Sea alga Polysiphonia violacea, and Compound 5 exhibited significant cytoxicity against human cancer cell lines. Expand
Massarilactones E-G, new metabolites from the endophytic fungus Coniothyrium sp., associated with the plant Artimisia maritima.
Three new massarilactones E-G (1-3) and the massarilactone acetonide (4) were isolated from the ethyl acetate extract of the endophytic fungus Coniothyrium sp., associated with the plant ArtimisiaExpand
Metabolites of the Marine Fungus Asperigillus varians KMM 4630
Microscopic marine fungi are rich sources of various biologically active compounds [1-3]. In searching for these compounds in fungi isolated frm various marine habitats, we observed that theExpand
Biologically Active Metabolites from Fungi 61); Phomosines A-C Three New Biaryl Ethers from Phomopsis sp
Abstract Phomosines A-C, three new biaryl ethers have been isolated from the endophytic fungus Phomopsis sp‥
Fungi from marine sponges: diversity, biological activity and secondary metabolites
A high proportion of culture extracts of sponge-associated fungi was biologically active in tests to detect antifungal, antialgal, and antibacterial activity, cytotoxicity and inhibition of reverse-transcriptase and tyrosine kinase. Expand
Synthesis and biological evaluation of (+/-)-dinemasone C and analogues.
Dinemasone C was prepared in three steps (8% overall yield) from cis-tetrahydro-4-hydroxy-6-methyl-2-pyrone by aldol reaction with 2,4-hexadienal, epoxidation followed by cyclization, andExpand
Enantioselective total synthesis of epoxyquinone natural products (−)-phyllostine, (+)-epoxydon, (+)-epiepoxydon and (−)-panepophenanthrin: access to versatile chiral building blocks through enzymatic kinetic resolution
A new enzyme mediated protocol to access versatile chiral building blocks for the synthesis of epoxyquinone natural products is delineated. Total syntheses of (−)-phyllostine, (+)-epoxydon,Expand
Enantiopure trans-3-arylaziridine-2-carboxamides: preparation by bacterial hydrolysis and ring-openings toward enantiopure, unnatural D-α-amino acids.
Experimental evidence is provided that suggests the fate of the (2S,3R)-3-arylaziridine-2-carboxylic acids concomitantly formed during the resolution processes, which is partially re-examined. Expand