Antimicrobial Cathelicidin Peptide LL-37 Inhibits the LPS/ATP-Induced Pyroptosis of Macrophages by Dual Mechanism

@inproceedings{Hu2014AntimicrobialCP,
  title={Antimicrobial Cathelicidin Peptide LL-37 Inhibits the LPS/ATP-Induced Pyroptosis of Macrophages by Dual Mechanism},
  author={Zhongshuang Hu and Taisuke Murakami and Kaori Suzuki and Hiroshi Tamura and Kyoko Kuwahara-Arai and Toshiaki Iba and Isao Nagaoka},
  booktitle={PloS one},
  year={2014}
}
Pyroptosis is a caspase-1 dependent cell death, associated with proinflammatory cytokine production, and is considered to play a crucial role in sepsis. Pyroptosis is induced by the two distinct stimuli, microbial PAMPs (pathogen associated molecular patterns) and endogenous DAMPs (damage associated molecular patterns). Importantly, cathelicidin-related AMPs (antimicrobial peptides) have a role in innate immune defense. Notably, human cathelicidin LL-37 exhibits the protective effect on the… CONTINUE READING
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