Antimicrobial Agents in Saliva—Protection for the Whole Body

  title={Antimicrobial Agents in Saliva—Protection for the Whole Body},
  author={Jorma O. Tenovuo},
  journal={Journal of Dental Research},
  pages={807 - 809}
  • J. Tenovuo
  • Published 1 December 2002
  • Medicine, Art
  • Journal of Dental Research
The author describes his involvement in the discovery of antimicrobial agents in the human mouth. 

The antioxidant and peroxidase activities of saliva in patients with inflammatory periodontal diseases and possibility of their correction

Antioxidant activity of saliva was significantly decreased in the last two groups and so its was corrected by means of xidiphone.

Exposure of Microflora Present in Various Habitants and its Drug Designing Studies

The Micro flora isolated from the clinical samples like infectious blood and Buccal samples from different habitants and con firmed through different biochemical characterizations. The blood samples

Saliva and Oral Health

Saliva is an important fluid that play an essential role in maintaining the integrity of the oral structures and the human body as whole and serves a wide spectrum of physiological needs to protect the oral mucosa and the whole body from infection.

Elderly nutritional status effection salivary anticandidal capacity against Candida albicans

Although does not cause significant decrease of salivary total protein, malnutrition in elderly results in lower capacity of saliva in inhibiting the growth and declining the virulence of C. albicans.


The morning saliva samples collected and inoculated in the optimized Nutrient medium, incubated at 37 ± 2°C for 24 hours showed the organisms with specific gram character using Gram’s staining


The biological fluid, saliva confirmed the presence of cocci which were proven to be possessing potent antibacterial properties for immune and non3immune defence systems.

The effect of acute ethanol intoxication on salivary proteins of innate and adaptive immunity.

This report is the first to show that acute ingestion of relatively large, yet tolerable dose of alcohol, significantly disturbs salivary antimicrobial defense system and may contribute to increased susceptibility to infections, when acute alcohol intake coincides with exposure to pathogens.

[The effects of moisturizing gel to prevent dry mouth in patients with cerebrovascular disease].

  • E. SudoI. Maejima
  • Medicine
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
  • 2008
It is suggested that oral care using a moisturizing gel might contribute to prevention of respiratory tract infections by oral contamination due to cerebrovascular disease.

Original Contribution Intragastric generation of antimicrobial nitrogen oxides from saliva—Physiological and therapeutic considerations

Saliva rich in nitrite enhances the bactericidal effects of gastric juice, possibly through the generation of reactive nitrogen intermediates, including NO, which may be useful for restoring gastric NO levels and host defense in critically ill patients.



Clinical applications of antimicrobial host proteins lactoperoxidase, lysozyme and lactoferrin in xerostomia: efficacy and safety.

In this review, the clinical efficacy and safety of this kind of preventive approach against various oral diseases and symptoms is critically evaluated.

The role of saliva in maintaining oral homeostasis.

  • I. Mandel
  • Medicine
    Journal of the American Dental Association
  • 1989
Salivary composition and function is discussed in a broad perspective, relating them to clinical concerns and current research as well as its relation to oral disease.

Saliva: its role in health and disease.

A clinically oriented review of the literature on the role of saliva in the upper gastrointestinal tract is presented and the many problems associated with lack of saliva are reviewed.

A Mouthrinse which Optimizes in vivo Generation of Hypothiocyanite

The volume of the rinse, the H2O2 concentrations, and the pH were shown to be determinants of the concentration of OSCN- generated by the rinse.

The Peroxidase System in Human Tears

Inhibition of dental plaque acid production by the salivary lactoperoxidase antimicrobial system

Resting human whole saliva inhibited acid production by glucose-stimulated, homologous plaque. The degree of inhibition of plaque acid production correlated positively with the concentration of

Xylitol-Induced Increase of Lactoperoxidase Activity

Persons who were fed a strict diet with regard to the type of sweeteners used (sucrose, fructose, and xylitol) displayed differences in salivary peroxidase activity. Xylitol consumption considerably

Saliva--the defender of the oral cavity.

This mini-review, primarily dealing with the defensive systems in saliva, will focus on mucous oral epithelia and the protective functions of the peptides and of the (glyco)proteins of the innate immune system, contributing to the ®rst line of oral defence.

Endogenous mucosal antiviral factors of the oral cavity.

  • D. Shugars
  • Medicine, Biology
    The Journal of infectious diseases
  • 1999
Characterization of SLPI and other endogenous antiviral molecules may enhance the understanding of factors influencing mucosal HIV-1 transmission and protect adherent monocytes and activated peripheral blood mononuclear cells against HIV- 1 infection.

Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis: a phase-2 multi-center study.

Data suggest that P-113 mouthrinse is safe and reduces the development of gingival bleeding, gingivitis and plaque in the human experimental gingIVitis model.