Antimicrobial Activity of 3D-Printed Poly(ɛ-Caprolactone) (PCL) Composite Scaffolds Presenting Vancomycin-Loaded Polylactic Acid-Glycolic Acid (PLGA) Microspheres

@inproceedings{Zhou2018AntimicrobialAO,
  title={Antimicrobial Activity of 3D-Printed Poly(ɛ-Caprolactone) (PCL) Composite Scaffolds Presenting Vancomycin-Loaded Polylactic Acid-Glycolic Acid (PLGA) Microspheres},
  author={Zhi Zhou and Qingqiang Yao and Lan Li and X Zhang and Bo Wei and Li Yuan and Liming Wang},
  booktitle={Medical science monitor : international medical journal of experimental and clinical research},
  year={2018}
}
BACKGROUND The aim of this study was to design and test a novel composite scaffold with antibacterial efficacy for treating bone infections using a three-dimensional (3D) printed poly(ε-caprolactone) (PCL) scaffold coated with polydopamine (PDA) for the adsorption of polylactic acid-glycolic acid (PLGA) microspheres loaded with vancomycin. MATERIAL AND METHODS Vancomycin-loaded PLGA microspheres were produced by the double-emulsion method, and microsphere morphology, drug-loading dosage… CONTINUE READING

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