Antimicrobial Actions of the Nadph Phagocyte Oxidase and Inducible Nitric Oxide Synthase in Experimental Salmonellosis. II. Effects on Microbial Proliferation and Host Survival in Vivo

@article{Mastroeni2000AntimicrobialAO,
  title={Antimicrobial Actions of the Nadph Phagocyte Oxidase and Inducible Nitric Oxide Synthase in Experimental Salmonellosis. II. Effects on Microbial Proliferation and Host Survival in Vivo},
  author={Pietro Mastroeni and Andr{\'e}s V{\'a}zquez-Torres and Ferric C Fang and Yisheng Xu and Shahid Aziz Anwar Khan and Carlos E. Hormaeche and Gordon Dougan},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={192},
  pages={237 - 248}
}
The roles of the NADPH phagocyte oxidase (phox) and inducible nitric oxide synthase (iNOS) in host resistance to virulent Salmonella typhimurium were investigated in gp91phox(-/)-, iNOS(-/)-, and congenic wild-type mice. Although both gp91phox(-/)- and iNOS(-/)- mice demonstrated increased susceptibility to infection with S. typhimurium compared with wild-type mice, the kinetics of bacterial replication were dramatically different in the gp91phox(-/)- and iNOS(-/)- mouse strains. Greater… CONTINUE READING

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